The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition

The degradation of the poly(A) tail is crucial for posttranscriptional gene regulation and for quality control of mRNA. Poly(A)-specific ribonuclease (PARN) is one of the major mammalian 3′ specific exo-ribonucleases involved in the degradation of the mRNA poly(A) tail, and it is also involved in th...

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Hlavní autoři: Nagata, Takashi, Suzuki, Sakura, Endo, Ryuta, Shirouzu, Mikako, Terada, Takaho, Inoue, Makoto, Kigawa, Takanori, Kobayashi, Naohiro, Güntert, Peter, Tanaka, Akiko, Hayashizaki, Yoshihide, Muto, Yutaka, Yokoyama, Shigeyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504292/
https://ncbi.nlm.nih.gov/pubmed/18641416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn458
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