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An ATP-gate controls tubulin binding by the tethered head of kinesin-1
Kinesin-1 is a 2-headed molecular motor that walks along microtubules, with each step gated by ATP binding. Existing models for the gating mechanism propose a role for the microtubule lattice. We show that unpolymerised tubulin binds to kinesin-1, causing tubulin-activated ADP release. With no added...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2504013/ https://ncbi.nlm.nih.gov/pubmed/17412962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1136985 |
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