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Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

Two isoforms of human interleukin 15 (IL-15) exist. One isoform has a shorter putative signal peptide (21 amino acids) and its transcript shows a tissue distribution pattern that is distinct from that of the alternative IL-15 isoform with a 48-aa signal peptide. The 21-aa signal isoform is preferent...

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Publicado en:Proc Natl Acad Sci U S A
Principais autores: Tagaya, Yutaka, Kurys, Gloria, Thies, Tiffany A., Losi, Jacqueline M., Azimi, Nazli, Hanover, John A., Bamford, Richard N., Waldmann, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1997
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25016/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405632/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14444
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