Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study

BACKGROUND: Rare mutations of the low-density lipoprotein receptor gene (LDLR) cause familial hypercholesterolemia, which increases the risk for coronary artery disease (CAD). Less is known about the implications of common genetic variation in the LDLR gene regarding the variability of cholesterol l...

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Main Authors: Linsel-Nitschke, Patrick, Götz, Anika, Erdmann, Jeanette, Braenne, Ingrid, Braund, Peter, Hengstenberg, Christian, Stark, Klaus, Fischer, Marcus, Schreiber, Stefan, El Mokhtari, Nour Eddine, Schaefer, Arne, Schrezenmeier, Jürgen, Rubin, Diana, Hinney, Anke, Reinehr, Thomas, Roth, Christian, Ortlepp, Jan, Hanrath, Peter, Hall, Alistair S., Mangino, Massimo, Lieb, Wolfgang, Lamina, Claudia, Heid, Iris M., Doering, Angela, Gieger, Christian, Peters, Annette, Meitinger, Thomas, Wichmann, H.-Erich, König, Inke R., Ziegler, Andreas, Kronenberg, Florian, Samani, Nilesh J., Schunkert, Heribert
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2500189/
https://ncbi.nlm.nih.gov/pubmed/18714375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002986
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