PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice

Background: Homocysteine (Hcy) is an independent cardiovascular risk factor; however, in diabetes, the role of tissue Hcy leading to cardiac dysfunction is unclear. Aims: To determine whether tissue Hcy caused endothelial-myocyte uncoupling and ventricular dysfunction in diabetes. Methods: Diabetes...

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Hauptverfasser: Rodriguez, Walter E., Sen, Utpal, Tyagi, Neetu, Kumar, Munish, Carneal, Gene, Aggrawal, Deep, Newsome, Justin, Tyagi, Suresh C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2008
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2500152/
https://ncbi.nlm.nih.gov/pubmed/18690293
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