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Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel

The voltage-gated sodium channel is the site of action of more than six classes of neurotoxins and drugs that alter its function by interaction with distinct, allosterically coupled receptor sites. Batrachotoxin (BTX) is a steroidal alkaloid that binds to neurotoxin receptor site 2 and causes persis...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Linford, Nancy J., Cantrell, Angela R., Qu, Yusheng, Scheuer, Todd, Catterall, William A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24981/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811906/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13947
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