ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo

BACKGROUND: Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1α and STAT3 have been implicated in HCC progression, thus representing interesting t...

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Main Authors: Moser, Christian, Lang, Sven A, Mori, Akira, Hellerbrand, Claus, Schlitt, Hans J, Geissler, Edward K, Fogler, William E, Stoeltzing, Oliver
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2496914/
https://ncbi.nlm.nih.gov/pubmed/18651980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-206
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