Covalent Binding to Tubulin by Isothiocyanates: A MECHANISM OF CELL GROWTH ARREST AND APOPTOSIS

Isothiocyanates (ITCs) found in cruciferous vegetables, including benzyl-ITC (BITC), phenethyl-ITC (PEITC), and sulforaphane (SFN), inhibit carcinogenesis in animal models and induce apoptosis and cell cycle arrest in various cell types. The biochemical mechanisms of cell growth inhibition by ITCs a...

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Main Authors: Mi, Lixin, Xiao, Zhen, Hood, Brian L., Dakshanamurthy, Sivanesan, Wang, Xiantao, Govind, Sudha, Conrads, Thomas P., Veenstra, Timothy D., Chung, Fung-Lung
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2008
主題:
Molecular Basis of Cell and Developmental Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494917/
https://ncbi.nlm.nih.gov/pubmed/18524779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802330200
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