Overexpression of the PDZ1 Domain of PDZK1 Blocks the Activity of Hepatic Scavenger Receptor, Class B, Type I by Altering Its Abundance and Cellular Localization

PDZK1 is a four-PDZ domain-containing scaffold protein that, via its first PDZ domain (PDZ1), binds to the C terminus of the high density lipoprotein (HDL) receptor scavenger receptor, class B, type I (SR-BI). Abolishing PDZK1 expression in PDZK1 knock-out (KO) mice leads to a post-transcriptional,...

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Hlavní autoři: Fenske, Sara A., Yesilaltay, Ayce, Pal, Rinku, Daniels, Kathleen, Rigotti, Attilio, Krieger, Monty, Kocher, Olivier
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494912/
https://ncbi.nlm.nih.gov/pubmed/18544532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800029200
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