Mutations which alter the level or structure of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner.

Two mutants of Sindbis virus have been isolated which grow inefficiently at 34.5 degrees C in mosquito cells yet replicate normally in chicken embryo fibroblast cells at the same temperature. In addition, these mutants exhibit temperature-sensitive growth in both cell types and are RNA- at the nonpe...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Lemm, J A, Durbin, R K, Stollar, V, Rice, C M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249484/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2159558/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.6.3001-3011.1990
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