Hypercontractility and impaired sildenafil relaxations in the BK(Ca) channel deletion model of erectile dysfunction

Erectile dysfunction (ED) can be elicited by a variety of pathogenic factors, particularly impaired formation of and responsiveness to nitric oxide (NO) and the downstream effectors soluble guanylate cyclase (sGC) and cGMP-dependent protein kinase I (PKGI). One important target of PKGI in smooth mus...

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Detalhes bibliográficos
Main Authors: Werner, Matthias E., Meredith, Andrea L., Aldrich, Richard W., Nelson, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Developmental Physiology and Pregnancy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494801/
https://ncbi.nlm.nih.gov/pubmed/18480246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00173.2008
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