The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis

High-capacity mitochondrial ATP production is essential for normal function of the adult heart, and evidence is emerging that mitochondrial derangements occur in common myocardial diseases. Previous overexpression studies have shown that the inducible transcriptional coactivator peroxisome prolifera...

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Main Authors: Lehman, John J., Boudina, Sihem, Banke, Natasha Hausler, Sambandam, Nandakumar, Han, Xianlin, Young, Deanna M., Leone, Teresa C., Gross, Richard W., Lewandowski, E. Douglas, Abel, E. Dale, Kelly, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2008
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494758/
https://ncbi.nlm.nih.gov/pubmed/18487436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00081.2008
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