The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis

High-capacity mitochondrial ATP production is essential for normal function of the adult heart, and evidence is emerging that mitochondrial derangements occur in common myocardial diseases. Previous overexpression studies have shown that the inducible transcriptional coactivator peroxisome prolifera...

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Hlavní autoři: Lehman, John J., Boudina, Sihem, Banke, Natasha Hausler, Sambandam, Nandakumar, Han, Xianlin, Young, Deanna M., Leone, Teresa C., Gross, Richard W., Lewandowski, E. Douglas, Abel, E. Dale, Kelly, Daniel P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494758/
https://ncbi.nlm.nih.gov/pubmed/18487436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00081.2008
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