Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism

OBJECTIVE—Fluxes through mitochondrial pathways are defective in insulin-resistant skeletal muscle, but it is unclear whether similar mitochondrial defects play a role in the liver during insulin resistance and/or diabetes. The purpose of this study is to determine whether abnormal mitochondrial met...

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Hlavní autoři: Satapati, Santhosh, He, TianTeng, Inagaki, Takeshi, Potthoff, Matthew, Merritt, Matthew E., Esser, Victoria, Mangelsdorf, David J., Kliewer, Steven A., Browning, Jeffrey D., Burgess, Shawn C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2008
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494699/
https://ncbi.nlm.nih.gov/pubmed/18469201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0226
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