Activation of Peroxisome Proliferator–Activated Receptor β/δ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-κB Activity via Extracellular Signal–Related Kinase 1/2

OBJECTIVE—Chronic activation of the nuclear factor-κB (NF-κB) in white adipose tissue leads to increased production of pro-inflammatory cytokines, which are involved in the development of insulin resistance. It is presently unknown whether peroxisome proliferator–activated receptor (PPAR) β/δ activa...

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Main Authors: Rodríguez-Calvo, Ricardo, Serrano, Lucía, Coll, Teresa, Moullan, Norman, Sánchez, Rosa M., Merlos, Manuel, Palomer, Xavier, Laguna, Juan C., Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2008
Assuntos:
Pathophysiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494695/
https://ncbi.nlm.nih.gov/pubmed/18443198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0176
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