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Caspase activity mediates the differentiation of embryonic stem cells

Embryonic stem (ES) cells are capable of indefinite self-renewal while retaining the ability to differentiate to any of the three germ layers that give rise to all somatic cell types. An emerging view is that a core set of transcription factors, including Oct4, Sox2 and Nanog, form a robust autoregu...

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Detalhes bibliográficos
Main Authors: Fujita, Jun, Crane, Ana M., Souza, Marlon K., Dejosez, Marion, Kyba, Michael, Flavell, Richard A., Thomson, James A., Zwaka, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494585/
https://ncbi.nlm.nih.gov/pubmed/18522852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.04.001
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