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Structure and function in rhodopsin: Rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state

The Glu-134–Arg-135 residues in rhodopsin, located near the cytoplasmic end of the C helix, are involved in G protein binding, or activation, or both. Furthermore, the charge-neutralizing mutation Glu-134 to Gln-134 produces hyperactivity in the activated state and produces constitutive activity in...

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Detalhes bibliográficos
Main Authors: Kim, Jong-Myoung, Altenbach, Christian, Thurmond, Robin L., Khorana, H. Gobind, Hubbell, Wayne L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24937/
https://ncbi.nlm.nih.gov/pubmed/9405602
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