Repeated betamethasone treatment of pregnant sheep programs persistent reductions in circulating IGF-I and IGF-binding proteins in progeny

Exposure to synthetic glucocorticoids in utero markedly improves survival after preterm birth, but repeated exposures impair fetal and postnatal growth and are associated with evidence of insulin resistance in later life. The insulin-like growth factor (IGF) axis is an important regulator of growth...

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Detalhes bibliográficos
Main Authors: Gatford, Kathryn L., Owens, Julie A., Li, Shaofu, Moss, Timothy J. M., Newnham, John P., Challis, John R. G., Sloboda, Deborah M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493590/
https://ncbi.nlm.nih.gov/pubmed/18492775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00047.2008
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