Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy

Angiopoietins were thought to be endothelial cell-specific via the tie2 receptor. We showed that angiopoietin-1 (ang1) also interacts with integrins on cardiac myocytes (CMs) to increase survival. Because ang1 monomers bind and activate integrins (not tie2), we determined their function in vivo. We...

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Main Authors: Dallabrida, Susan M., Ismail, Nesreen S., Pravda, Elke A., Parodi, Emily M., Dickie, Renee, Durand, Ellen M., Lai, Jean, Cassiola, Flavia, Rogers, Rick A., Rupnick, Maria A.
格式: Artigo
語言:Inglês
出版: The Federation of American Societies for Experimental Biology 2008
主題:
Research Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493452/
https://ncbi.nlm.nih.gov/pubmed/18502941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-100966
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