Neurodegenerative disease induced by the wild mouse ecotropic retrovirus is markedly accelerated by long terminal repeat and gag-pol sequences from nondefective Friend murine leukemia virus.

The wild mouse ecotropic retrovirus (WM-E) induces a spongiform neurodegenerative disease in mice after a variable incubation period of 2 months to as long as 1 year. We isolated a molecular clone of WM-E (15-1) which was weakly neurovirulent (incidence, 8%) but was highly leukemogenic (incidence, 4...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Portis, J L, Czub, S, Garon, C F, McAtee, F J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249301/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2181155/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.4.1648-1656.1990
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