Enriched enrolment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review

AIMS: Enriched enrolment study designs have been suggested to be useful for proof of concept when only a proportion of the diseased population responds to a treatment intervention. We aim to investigate whether this really is the case in trials of pregabalin and gabapentin in neuropathic pain. METHO...

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Main Authors: Straube, Sebastian, Derry, Sheena, McQuay, Henry J, Moore, R Andrew
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2008
Fag:
Methods in Clinical Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492925/
https://ncbi.nlm.nih.gov/pubmed/18489611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03200.x
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