Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.

In order to elucidate the molecular mechanisms of action of the tat-responsive sequence, mutational analysis of the tat-responsive sequence was carried out. The most critical region comprised nucleotides +18 to +44 and included the 3-nucleotide bulge at positions +23 to +25, the loop sequence, and a...

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Detalles Bibliográficos
Main Authors: Roy, S, Parkin, N T, Rosen, C, Itovitch, J, Sonenberg, N
Formato: Artigo
Idioma:Inglês
Publicado: 1990
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC249266/
https://ncbi.nlm.nih.gov/pubmed/2406460
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