Limited expression of poliovirus by vaccinia virus recombinants due to inhibition of the vector by proteinase 2A.
A recombinant vaccinia virus was constructed that expressed poliovirus coat precursor protein P1 fused to about two-thirds of the 2A proteinase. The truncated 2A segment could be cleaved away from the P1 region by coinfecting with poliovirus type 1, 2, or 3 or with human rhinovirus 14 but not with e...
Shranjeno v:
| izdano v: | J Virol |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology (ASM)
1990
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249263/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2154618/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.3.1388-1393.1990 |
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