Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity.

Mutant gp120 glycoproteins exhibiting a range of affinities for CD4 were tested for ability to form syncytia and to complement an env-defective provirus for replication. Surprisingly, gp120 mutants that efficiently induced syncytia and/or complemented virus replication were identified that exhibited...

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Détails bibliographiques

Publié dans:	J Virol
Auteurs principaux:	Thali, M, Olshevsky, U, Furman, C, Gabuzda, D, Li, J, Sodroski, J
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1991
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248964/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1870209/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.9.5007-5012.1991
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