Vaccinia Viruses with Mutations in the E3L Gene as Potential Replication-Competent, Attenuated Vaccines: Scarification Vaccination

In this study, we evaluated the efficacy of vaccinia virus (VACV) containing mutations in the E3L virulence gene to protect mice against a lethal poxvirus challenge after vaccination by scarification. VACV strains with mutations in the E3L gene had significantly decreased pathogenicity, even in immu...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Jentarra, Garilyn M., Heck, Michael C., Youn, Jin Won, Kibler, Karen, Langland, Jeffrey O., Baskin, Carole R., Ananieva, Olga, Chang, Yung, Jacobs, Bertram L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2008
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2488381/
https://ncbi.nlm.nih.gov/pubmed/18455281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.03.044
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