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Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein.

The interferon-induced murine Mx1 protein, which is localized in the nucleus, most likely specifically blocks influenza virus replication by inhibiting nuclear viral mRNA synthesis, including the mRNA synthesis catalyzed by inoculum (parental) virion nucleocapsids (R. M. Krug, M. Shaw, B. Broni, G....

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Udgivet i:J Virol
Principais autores: Broni, B, Julkunen, I, Condra, J H, Davies, M E, Berry, M J, Krug, R M
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248816/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2243397/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.12.6335-6340.1990
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