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Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing

Mutant, but not wild-type p53 binds with high affinity to a variety of MAR-DNA elements (MARs), suggesting that MAR-binding of mutant p53 relates to the dominant-oncogenic activities proposed for mutant p53. MARs recognized by mutant p53 share AT richness and contain variations of an AATATATTT “DNA-...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Will, Katrin, Warnecke, Gabriele, Wiesmüller, Lisa, Deppert, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24879/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811860/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13681
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