Characterization of two patched receptors for the vertebrate hedgehog protein family

The multitransmembrane protein Patched (PTCH) is the receptor for Sonic Hedgehog (Shh), a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. Current models suggest that binding of Shh to PTCH prevents the normal inhibition of the seven-transmembrane-protein S...

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Main Authors: Carpenter, David, Stone, Donna M., Brush, Jennifer, Ryan, Anne, Armanini, Mark, Frantz, Gretchen, Rosenthal, Arnon, de Sauvage, Frederic J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 1998
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC24870/
https://ncbi.nlm.nih.gov/pubmed/9811851
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