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Non-redundant function of the MEK5–ERK5 pathway in thymocyte apoptosis
The mitogen-activated protein kinases (MAPKs) ERK1/2, p38, and JNK are thought to determine survival-versus-death fate in developing thymocytes. However, this view was challenged by studies using ‘MEK1-ERK1/2-specific' pharmacological inhibitors, which block both positive and negative selection...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2486421/ https://ncbi.nlm.nih.gov/pubmed/18548009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.114 |
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