Human Cytomegalovirus UL18 Utilizes US6 for Evading the NK and T-Cell Responses

Human cytomegalovirus (HCMV) US6 glycoprotein inhibits TAP function, resulting in down-regulation of MHC class I molecules at the cell surface. Cells lacking MHC class I molecules are susceptible to NK cell lysis. HCMV expresses UL18, a MHC class I homolog that functions as a surrogate to prevent ho...

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Detalhes bibliográficos
Main Authors: Kim, Youngkyun, Park, Boyoun, Cho, Sunglim, Shin, Jinwook, Cho, Kwangmin, Jun, Youngsoo, Ahn, Kwangseog
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483941/
https://ncbi.nlm.nih.gov/pubmed/18688275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000123
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