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Human Cytomegalovirus UL18 Utilizes US6 for Evading the NK and T-Cell Responses
Human cytomegalovirus (HCMV) US6 glycoprotein inhibits TAP function, resulting in down-regulation of MHC class I molecules at the cell surface. Cells lacking MHC class I molecules are susceptible to NK cell lysis. HCMV expresses UL18, a MHC class I homolog that functions as a surrogate to prevent ho...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2483941/ https://ncbi.nlm.nih.gov/pubmed/18688275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000123 |
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