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The “Electrostatic-Switch” Mechanism: Monte Carlo Study of MARCKS-Membrane Interaction

The binding of the myristoylated alanine-rich C kinase substrate (MARCKS) to mixed, fluid, phospholipid membranes is modeled with a recently developed Monte Carlo simulation scheme. The central domain of MARCKS is both basic (ζ = +13) and hydrophobic (five Phe residues), and is flanked with two long...

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Detalles Bibliográficos
Main Authors: Tzlil, Shelly, Murray, Diana, Ben-Shaul, Avinoam
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483737/
https://ncbi.nlm.nih.gov/pubmed/18502797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.132522
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