Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways

Human T-cell leukemia virus type-1 (HTLV-1) induces adult T-cell leukemia/lymphoma (ATL/L), a fatal lymphoproliferative disorder, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic progressive disease of the central nervous system after a long period of latent infecti...

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Autori principali: Agbottah, Emmanuel, Yeh, Wen-I, Berro, Reem, Klase, Zachary, Pedati, Caitlin, Kehn-Hall, Kyleen, Wu, Weilin, Kashanchi, Fatah
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483717/
https://ncbi.nlm.nih.gov/pubmed/18544167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-5-12
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