Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB

RNA interference (RNAi) acts constitutively to silence the innate immune response, and innate immunity genes are misregulated in Dicer-deficient Caenorhabditis elegans. Here, we show that inhibition of Dicer expression by RNAi in human cells up-regulates major histocompatibility complex class I–rela...

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Detalhes bibliográficos
Main Authors: Tang, Kai-Fu, Ren, Hong, Cao, Jia, Zeng, Gui-Li, Xie, Jing, Chen, Min, Wang, Lu, He, Cai-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483517/
https://ncbi.nlm.nih.gov/pubmed/18644891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200801169
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