Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin–mediated cell adhesion during Drosophila heart tube lumen formation

During Drosophila melanogaster heart development, a lumen forms between apical surfaces of contralateral cardioblasts (CBs). We show that Slit and its receptor Roundabout (Robo) are required at CB apical domains for lumen formation. Mislocalization of Slit outside the apical domain causes ectopic lu...

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Autores principales: Santiago-Martínez, Edgardo, Soplop, Nadine H., Patel, Rajesh, Kramer, Sunita G.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2008
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483515/
https://ncbi.nlm.nih.gov/pubmed/18663139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200804120
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