IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells

The development of infectious cDNA for different alphaviruses opened an opportunity to explore their attenuation by extensively modifying the viral genomes, an approach that might minimize or exclude the reversion to the wild-type, pathogenic phenotype. Moreover, the genomes of such alphaviruses can...

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Hlavní autoři: Volkova, Eugenia, Frolova, Elena, Darwin, Justin, Forrester, Naomi L., Weaver, Scott C., Frolov, Ilya
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483425/
https://ncbi.nlm.nih.gov/pubmed/18501401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.04.020
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