Propagating structure of Alzheimer’s β-amyloid((10–35)) is parallel β-sheet with residues in exact register
The pathognomonic plaques of Alzheimer’s disease are composed primarily of the 39- to 43-aa β-amyloid (Aβ) peptide. Crosslinking of Aβ peptides by tissue transglutaminase (tTg) indicates that Gln(15) of one peptide is proximate to Lys(16) of another in aggregated Aβ. Here we report how the fibril st...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1998
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24832/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811813/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13407 |
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