Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes

T-cell large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of CD3(+)CD8(+) cells. Leukemic LGLs correspond to terminally differentiated effector-memory cytotoxic T lymphocytes (CTLs) that escape Fas-mediated activation-induced cell death (AICD) in vivo. The gene expression...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shah, Mithun Vinod, Zhang, Ranran, Irby, Rosalyn, Kothapalli, Ravi, Liu, Xin, Arrington, Ty, Frank, Bryan, Lee, Norman H., Loughran, Thomas P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2008
Pynciau:
Neoplasia
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481553/
https://ncbi.nlm.nih.gov/pubmed/18477771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-121871
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