Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2

Chemoresistance and therapeutic selectivity are major obstacles to successful chemotherapy of ovarian cancer. Manganese superoxide disumutase (MnSOD) is an important antioxidant enzyme responsible for the elimination of superoxide radicals. We reported here that MnSOD was significantly elevated in o...

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Detalhes bibliográficos
Main Authors: Yeung, B H Y, Wong, K Y, Lin, M C, Wong, C K C, Mashima, T, Tsuruo, T, Wong, A S T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2480972/
https://ncbi.nlm.nih.gov/pubmed/18594523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604477
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