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Investigating the Mechanism of Peptide Aggregation: Insights from Mixed Monte Carlo-Molecular Dynamics Simulations

The early stages of peptide aggregation are currently not accessible by experimental techniques at atomic resolution. In this article, we address this problem through the application of a mixed simulation scheme in which a preliminary coarse-grained Monte Carlo analysis of the free-energy landscape...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Meli, Massimiliano, Morra, Giulia, Colombo, Giorgio
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2480662/
https://ncbi.nlm.nih.gov/pubmed/18263661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.121061
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