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Function of Semliki Forest virus E3 peptide in virus assembly: replacement of E3 with an artificial signal peptide abolishes spike heterodimerization and surface expression of E1.

The Semliki Forest virus spike glycoproteins E1 and p62 form a heterodimeric complex in the endoplasmic reticulum (ER) and are transported as such to the cell surface. In the mature virus particle, the heterodimeric association of E1 and E2 (the cleavage product of p62) is maintained, but as a more...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Lobigs, M, Zhao, H X, Garoff, H
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247902/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2200886/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.9.4346-4355.1990
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