Estradiol repression of tumor necrosis factor-α transcription requires estrogen receptor activation function-2 and is enhanced by coactivators

The tumor necrosis factor-α (TNF-α) promoter was used to explore the molecular mechanisms of estradiol (E(2))-dependent repression of gene transcription. E(2) inhibited basal activity and abolished TNF-α activation of the TNF-α promoter. The E(2)-inhibitory element was mapped to the −125 to −82 regi...

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Bibliographic Details
Main Authors: An, Jinping, Ribeiro, Ralff C. J., Webb, Paul, Gustafsson, Jan-Åke, Kushner, Peter J., Baxter, John D., Leitman, Dale C.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC24790/
https://ncbi.nlm.nih.gov/pubmed/10611355
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