Virtual screening for novel COX-2 inhibitors using the ZINC database

Cyclooxygenase-2 (COX-2) enzyme binds to arachidonic acid and releases metabolites that are used to induce pain and inflammation. COX-2 selective inhibitors such as celecoxib, rofecoxib and valdecoxib are currently used to reduce inflammatory response. However, they lack anti-thrombotic activity and...

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Bibliografiska uppgifter
Huvudupphovsmän: Sudha, Kotaprolu Naga, Shakira, Mohammed, Prasanthi, Paturi, Sarika, Nalla, Kumar, Ch Narasimha, Babu, Padavala Ajay
Materialtyp: Artigo
Språk:Inglês
Publicerad: Biomedical Informatics Publishing Group 2008
Ämnen:
Hypothesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2478730/
https://ncbi.nlm.nih.gov/pubmed/18685718
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