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A High-Sensitivity Method for Detection and Measurement of HMGB1 Protein Concentration by High-Affinity Binding to DNA Hemicatenanes

BACKGROUND: Protein HMGB1, an abundant nuclear non-histone protein that interacts with DNA and has an architectural function in chromatin, was strikingly shown some years ago to also possess an extracellular function as an alarmin and a mediator of inflammation. This extracellular function has since...

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Bibliographic Details
Main Authors: Gaillard, Claire, Borde, Chloé, Gozlan, Joël, Maréchal, Vincent, Strauss, François
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2478715/
https://ncbi.nlm.nih.gov/pubmed/18682735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002855
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