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Generating Functional CD8+ T-cell Memory Response under Transient CD4+ T-cell deficiency: Implications for vaccination of immunocompromised individuals
Studies based on either MHC class II-knockout or CD4(+) T-cell depleted murine models have demonstrated a critical role for CD4(+) T-cells in the generation of CD8(+) T-cell memory. However, it is difficult to extend these findings to immunocompromised humans where a complete loss of CD4(+) T-cells...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2478698/ https://ncbi.nlm.nih.gov/pubmed/18506880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200737933 |
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