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Investigating selection on viruses: a statistical alignment approach

BACKGROUND: Two problems complicate the study of selection in viral genomes: Firstly, the presence of genes in overlapping reading frames implies that selection in one reading frame can bias our estimates of neutral mutation rates in another reading frame. Secondly, the high mutation rates we are li...

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Detalhes bibliográficos
Main Authors: de Groot, Saskia, Mailund, Thomas, Lunter, Gerton, Hein, Jotun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2478691/
https://ncbi.nlm.nih.gov/pubmed/18616801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-9-304
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