Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice

BACKGROUND: HO-1 participates in the degradation of heme. Its products can exert unique cytoprotective effects. Numerous tumors express high levels of HO-1 indicating that this enzyme might be a potential therapeutic target. In this study we decided to evaluate potential cytostatic/cytotoxic effects...

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Detalhes bibliográficos
Main Authors: Nowis, Dominika, Bugajski, Marek, Winiarska, Magdalena, Bil, Jacek, Szokalska, Angelika, Salwa, Pawel, Issat, Tadeusz, Was, Halina, Jozkowicz, Alicja, Dulak, Jozef, Stoklosa, Tomasz, Golab, Jakub
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2478682/
https://ncbi.nlm.nih.gov/pubmed/18620555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-197
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