A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner.
The v-src oncogene of Rous sarcoma virus (RSV) is able to transform both avian and mammalian cells, but the mutant allele v-src-L displays a host range dependence for transformation, transforming chicken but not rat cells with wild-type efficiency. This host range restriction can be detected by meas...
Shranjeno v:
| izdano v: | J Virol |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology (ASM)
1989
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247689/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2462061/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.1.338-348.1989 |
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