The Role of Rac2 in Regulating Neutrophil Production in the Bone Marrow and Circulating Neutrophil Counts

Circulating neutrophils are persistently higher in mice deficient in the small GTPase Rac2 than in wild-type (WT) mice. Therefore, we examined the mechanisms through which the small GTPase Rac2 regulates neutrophil production and release. Lethally irradiated WT mice reconstituted with a 50:50 mixtur...

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Main Authors: Gomez, John C., Soltys, Jindrich, Okano, Keiichi, Dinauer, Mary C., Doerschuk, Claire M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2008
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475787/
https://ncbi.nlm.nih.gov/pubmed/18583316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071059
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