Superoxide-Dependent Cathepsin Activation Is Associated with Hypertensive Myocardial Remodeling and Represents a Target for Angiotensin II Type 1 Receptor Blocker Treatment

The elastolytic activity of cathepsins in the myocardium is implicated in hypertensive heart failure (HF). Given that reactive oxygen species are also implicated in protease activation associated with cardiac remodeling, we examined the role of the reactive oxygen species-induced cathepsin activatio...

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Bibliographic Details
Main Authors: Cheng, Xian Wu, Murohara, Toyoaki, Kuzuya, Masafumi, Izawa, Hideo, Sasaki, Takeshi, Obata, Koji, Nagata, Kohzo, Nishizawa, Takao, Kobayashi, Masakazu, Yamada, Takashi, Kim, Weon, Sato, Kohji, Shi, Guo-Ping, Okumura, Kenji, Yokota, Mitsuhiro
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2008
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Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475774/
https://ncbi.nlm.nih.gov/pubmed/18583318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071126
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