Identification of Farnesyl Pyrophosphate and N-Arachidonylglycine as Endogenous Ligands for GPR92

A series of small compounds acting at the orphan G protein-coupled receptor GPR92 were screened using a signaling pathway-specific reporter assay system. Lipid-derived molecules including farnesyl pyrophosphate (FPP), N-arachidonylglycine (NAG), and lysophosphatidic acid were found to activate GPR92...

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Hlavní autoři: Oh, Da Young, Yoon, Jung Min, Moon, Mi Jin, Hwang, Jong-Ik, Choe, Han, Lee, Ju Yeon, Kim, Jae Il, Kim, Sunoh, Rhim, Hyewhon, O'Dell, David K., Walker, J. Michael, Na, Heung Sik, Lee, Min Goo, Kwon, Hyuk Bang, Kim, Kyungjin, Seong, Jae Young
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475705/
https://ncbi.nlm.nih.gov/pubmed/18499677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708908200
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