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An investigation into the pharmacokinetics of 3-mercaptopropionic acid and development of a steady-state chemical seizure model using in vivo microdialysis and electrophysiological monitoring

OBJECTIVES: The goal of the present study was to develop a chemical seizure model using the convulsant, 3-mercaptopropionic acid (3-MPA). A pharmacodynamics approach was taken, combining in vivo microdialysis sampling with electrophysiological methods to simultaneously monitor, in real-time, the 3-M...

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Autors principals: Crick, Eric W., Osorio, Ivan, Bhavaraju, Naresh C., Linz, Thomas H., Lunte, Craig E.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474737/
https://ncbi.nlm.nih.gov/pubmed/17382519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2007.02.003
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